Title: Kurkuma wissenschaftlich geprüft
Link: Kurkuma wissenschaftlich geprüft
Kurkuma wissenschaftlich geprüft
Friends of Sun.
It's me again, Mai, your trusted chemist.
Today, for once, not with a tea, but with a golden latte.
A turmeric latte.
Hmh.
This stuff isn't just 100% Instagramable, it is also said to be very healthy.
Turmeric, in English turmeric, is one of the healthiest spices in the world.
That's because it's in the exotic root at least 90 different active ingredients are included.
Do you have skin problems, hair loss or problems with extra pounds .
.
.
He held a 1 kilo bag of turmeric under my nose and meant: "Have a drink.
I've read, that's good.
" I claim that she has already saved me from illness.
Turmeric video.
Turmeric contains a molecule called curcumin.
Incidentally, that is also responsible for the intense yellow color, but not only that.
The list of what curcumin should help against is impressive.
Whenever a "miracle cure" to work against a whole list of diseases, should hit the bullshit-o-meter right away.
But the interesting thing about curcumin is that there are an incredible number of scientific studies also clinical studies with humans.
And that's rather untypical for a classic [ __ ] panacea.
So, get yourself a tea or a turmeric latte.
Make yourself comfortable, we'll look at science a little closer behind the golden stuff.
* Theme music * You will find countless articles about curcumin on the net.
And that there is a potential or promising active ingredient could be for various diseases, however what does that mean exactly? To understand that we first have to know how new active ingredients are discovered or identified.
I hope you made yourselves comfortable.
It's going to be a little excursion now, but believe me, it's worth it.
Because you hear about new therapies all the time.
What I'm about to tell you will often help you to be able to classify such messages better in the future, so .
.
.
To fight a disease I have to understand it first.
Let's say biologists find out a certain type of cancer caused by a particular mutated protein.
There are examples of this, ie to fight this cancer we have to turn off this mutated protein.
The protein is made the target.
So to the target or to the target.
We are now looking for an active ingredient who shoots this target, i.
e.
deactivates this protein.
Then the search begins.
# Here check a ha, here check a ha Screening simply means testing a large number of substances.
That means you take a bunch of molecules.
These can be natural or which, made in the laboratory, and throws them on the target and see if there is anything that turns the protein off.
You have to pay attention to what we need here, is a specific effect.
Example: I can break any protein by heating it up.
That's why heat is far from being an anti-cancer drug.
Because heat destroys any protein and not just targeted the mutated cancer protein.
And there are also molecules that have all sorts of effects.
They might bind a little to the mutated protein, but also 100 other proteins, and enter into chemical reactions in the cell with things they come across.
We do not need that.
We need a specific active ingredient which specifically switches off the mutated protein, but leaves everything else alone.
Fortunately, more and more proteins can be switched off in a targeted manner.
Because the switch is in a sense built into the protein structure.
A protein structure is like a large 3D origami.
And many proteins have a hole or a pocket.
Enzymes, for example, are proteins with such a pocket.
And the bag is where the magic happens.
Only certain molecules fit in this pocket.
Sometimes the system is compared to the lock and key principle.
And this keyhole, so this protein pocket it is to be attacked.
If a drug molecule now fits perfectly into this pocket, it can quasi dock and block the pocket.
This means that the enzyme can no longer carry out its activity and is thus switched off.
So, because one can only derive theoretically to a limited extent, what such a super-fitting molecule could look like, one proceeds with a screening according to the principle "Trying over studying".
You just try out a lot of molecules that could be a million or more.
Now you think how is that supposed to work? a million test tubes or what? In a sense, yes, only on a small scale.
You take 384 well plates like this, for example.
They're actually about that big and then in that case have 384 such small reagent vessels in there.
That would be a classic high-throughput screening.
High throughput screening.
There you have these plates and pipetting robots.
And they combine in the small reagent vessels the mutated protein with one of the million substances and hope that there is a potential active ingredient in it.
You screen the whole thing, filter the whole thing down and then goes to the next round with the positive hits.
One then takes cancer cells, for example and see if you can hit the molecules with the help Can stop growth or whether the enzyme is still active in the cells, when you add the hit molecule.
Chemists can then optimize the good molecules even further.
They put a few atoms in here and take a few out of there give them to the biologists, who test them in the cells, etc.
And after many, many years of work you might make it to the next step.
As a rule, tests are first carried out on mice.
Then they have this particular cancer.
You try to cure it and look for side effects.
And if in the end there are still molecules in the running, that look good, then you can into clinical trials.
Phew, this is what an active ingredient search can look like in general.
The question now is where exactly is the current state of research with curcumin? Or should I say .
.
.
Curcumin has been used in countless screenings so far noticeable as a positive hit.
For different targets.
Ie yes, the list I made at the beginning it was not invented by some "internet experts" it is actually based on scientific studies.
Even with a number of cell studies and some mouse studies also gave positive results.
But strangely enough so far there is no reliable data from human clinical trials.
If you've seen the video about cell phone radiation, you know that randomized controlled trials are the gold standard of studies.
Ha, gold standard! But none of these carefully conducted studies shows any benefits of curcumin.
What's going on there? It's not all gold that .
.
.
looks gold .
.
.
Nah, what? With all due care in the development of active ingredients there are nasty traps.
E.
g.
molecules, who are called "chemical con artists", so can denote chemical impostors or con artists.
Nasty fellows who lure us on the wrong track.
But to understand that, we need to dig deeper into chemistry.
# Advanced Chemistry Excuse me.
We talked about the targeted deactivation of proteins, e.
g.
by blocking the pocket.
But how do we know this is happening? You can't see proteins and molecules with the naked eye.
And there is also no microscope that is good enough to see if the molecule goes into your pocket.
But scientists are smart people and have developed various tests.
These tests are also called assays and thus you can indirectly "see" whether it worked.
For example, you add a dye, a fluorescent dye, which only becomes active when the protein is deactivated.
Ie if I add my test molecule and the solution turns green, I have a positive hit.
Or I see if cancer cells survive my test molecule.
If they die, it is also a positive result.
There are many different assays and you always have to do different ones to be sure.
But now there are these: molecules, which generate positive hits, but they do are false positive.
E.
g.
the solution turns green, but not, because my protein was turned off but because the molecule switched on the dye directly.
Or the cancer cell dies, but not because the molecule has interacted with the protein, but because the molecule generally destroys cell walls.
And some molecules are able to generate positive hits in many different assays.
Simply because they are chemically very diverse.
Chemically promiscuous, you could say.
Chemical impostors.
Resveratrol is such a molecule that shows false positive hits in all possible assays.
Resveratrol is the molecule that is said to make red wine so healthy.
We already have this video about whether red wine is healthy or not.
Because resveratrol and other "impostor molecules" make life so difficult for drug developers they even got an extra name, namely: Because they are just too painful if you waste time, money and work because of false hits, to find the wrong track.
Yeah, and now guess what's up with curcumin.
Curcumin is a pain in the book.
In this article, which appeared in Nature in 2014, Curcumin is listed under the worst offenders, the worst evildoers.
Its chemical promiscuity enables it to get through many test common assays.
It is generally not particularly stable.
Which means chemically, it is reactive.
There are four common ways which curcumin can easily break down.
And the secondary products can enter into chemical reactions again.
This also explains why curcumin is so successful in the pre-tests, but in many animal experiments and failed at the latest in clinical trials.
But when curcumin is so reactive and getting it on with everyone then isn't it poisonous too? A reactive substance is potentially harmful.
Because they react with everything in the body and can cause damage.
With curcumin and especially turmeric, the spice, but this is not the case.
At least only from concentrations which we practically cannot take in.
First, the spice contains turmeric only 1 to 6% curcumin.
But it is even less effective because the so-called bioavailability, so what really arrives in the body, is just 1%.
Most of it will .
.
.
Yeah, how should I put it? .
.
.
pooped.
At least you can save yourself that much.
So that's reassuring for any negative effects, but of course this also applies to positive effects.
Even if there were positive effects, the bioavailability of curcumin is so lousy anyway, that not much of it really gets through.
You have to supplement, you can increase the bioavailability, by combining it with a little pepper because of piperine.
But there is still a problem.
Curcumin breaks down far too quickly, because it's not particularly stable.
Active ingredients that are supposed to work in the body for a while, usually have a half-life of several hours.
With curcumin it is only a few minutes.
The only question left when you know all of this then why are there still so many studies? Good question! For the medicinal chemist Jonathan Baell is the publication of positive results of reactive impostor molecules comparable to Throwing rubbish on the street.
He speaks of pollution of scientific publications.
These are very harsh words now.
I would put it that way.
The research on curcumin is despite the abundance of studies still very early.
And although there are papers that warn of pain and also explicitly before curcumin, there is such a huge amount of positive papers that create such a false imbalance.
In addition, you have to say that that some scientists are happy when they have positive hits to show because unfortunately they are under incredible pressure publish positive results.
But we've already discussed the problem in this video.
For our everyday life this means: Turmeric Latte looks great.
But the ascription "miracle cure", that comes more from tradition and not from science.
And I want all the YouTubers and influencers who swear by it don't blame them for lying, for God's sake! But beneficial experiences from individuals are not proof of effectiveness.
If I'm fine after this bar, may that be due to the bar, but also to something else.
Unfortunately, nothing has been scientifically proven so far and therefore not approved.
If you have suggestions as to what I can scientifically test, Write it in the comments.
Until next week.
Stay safe.
I put it in the washing machine right away, but .
.
.
Turmeric forever, I guess.
Subtitle: ARD Text on behalf of Funk (2019)
Curcumin 2000 review
✓ http://www.lnk123.com/SH16aR
curcumin 2000,curcumin 2000x,curcumin 2000mg,curcumin 2000x side effects,curcumin 2000x reviews,turmeric curcumin 2000 mg,bell curcumin 2000x reviews,turmeric curcumin 2000,turmeric curcumin complex 2000 mg,carlyle turmeric curcumin 2000 mg,curcumin 2000 mg capsules
Kurkuma wissenschaftlich geprüft
You are reading the article of Kurkuma wissenschaftlich geprüft with the link address https://articlesresources.blogspot.com/2021/03/kurkuma-wissenschaftlich-gepruft.html